Comparison of combined urea and creatinine clearance and.
Calculating creatinine clearance There is considerable controversy as to which equation is best for estimating CL cr, what weight to use, and whether to round up the serum creatinine in the elderly.Please refer to the publications listed in the reference section for more in-depth discussion of these areas. The advantages of calculating CL cr from serum creatinine are.
The creatinine clearance is a widely used test to estimate the glomerular filtration rate (GFR). Creatinine is derived from the metabolism of creatine in skeletal muscle and from dietary meat; it is released into the circulation at a relatively constant rate and has a stable plasma concentration. Like inulin, creatinine is freely filtered across the glomerulus and is neither reabsorbed nor.
Creatinine clearance, clinical measurement used to estimate renal function, specifically the filtration rate of the glomeruli (clusters of blood vessels that are the primary filtering structures of the kidney). Creatinine is a chemical end product of creatine metabolism that is removed, or cleared, from blood plasma by glomeruli and is excreted in the urine.
Serum creatinine or calculated creatinine clearance are the most convenient estimates of GFR, requiring only a single blood sample. Measured creatinine clearance requires a 24-hour urinary collection while isotopic methods involve intravenous injection of a nuclear tracer, and two subsequent blood samples to estimate clearance. Both these methods are more expensive and less convenient to the.
Some studies have shown that utilizing the adjusted body weight improves accuracy compared to other commonly used equations in estimating the creatinine clearance in the elderly population. References: Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16(1):31-41; Davis GA, Chandler MH. Comparison of.
Creatinine clearance can be measured from serum creatinine and cre-atinine excretion, or estimated from serum cre-atinine using estimating equations. Measurement of creatinine clearance requires collection of a timed urine sample, which is inconvenient and frequently inaccurate. Repeated measurements of creatinine clearance may overcome some of.
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